Phospholipase a2 axonal regeneration
WebXu J, G-M Kim, Ahmed SH, Xu J, Yan P, Xu XM, Hsu CY (2001) Glucocorticoid receptor-mediated suppression of AP-1 activation and matrix metalloproteinase expression after … WebApr 1, 1993 · We have previously reported that antidepressants such as desipramine (DMI) induce axonal regeneration of brain noradrenergic neurons. In the present experiments, …
Phospholipase a2 axonal regeneration
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WebDec 1, 2003 · Phospholipase A (2) (PLA (2)) hydrolyzes phosphatidylcholine to lysophosphatidylcholine and arachidonic acid. The former can induce myelin breakdown … WebWith appropriate injury models and retrograde tracing techniques to transport tracers from axon terminal to the soma, neuronal origin of targeted axons can be determined. After tracing, tissue is collected following appropriate survival time.
WebThis event correlates with upregulation of cytosolic and secreted forms of phospholipase A2 in Schwann cells (SC; De et al., 2003), ... In other words, axonal regeneration in pre-injured primary DRG sensory neurons is greater at 0.2 μM than at 2 μM roscovitine, and 2 μM elicited greater axon regrowth than 10 μM. ... WebThis thesis deals with processes coupled to injury in the peripheral nervous system (PNS), with a general aim to investigate the role of phospholipase A2 (PLA2) enzymes in axonal outgrowth. The axonal outgrowth of dorsal root ganglia (DRG) neurons in vitro was reduced by several different inhibitors of PLA2 activity and enhanced by an activator of this enzyme.
WebSecretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration ( PubMed: 10455175, PubMed: 10681567, PubMed: 2925633 ). WebJan 20, 2015 · Complete regeneration is achieved in mice within 8–10 d . Tpx and β-Btx are representative of a large family of presynaptic snake neurotoxins endowed with phospholipase A2 activity (SPANs), which are important, although neglected, human pathogens (12–15).
WebApr 1, 1993 · We have previously reported that antidepressants such as desipramine (DMI) induce axonal regeneration of brain noradrenergic neurons. In the present experiments, the role of phospholipase A2 (PLA2) in the regeneration of …
WebFig. 1 A: The group IA phospholipase A2 (PLA2) with phospholipid substrate modeled in the active site. The active site residues His-48 and Asp-93 and the bound Ca2+ is shown in purple. Ca2+ is bound by Asp-49 as well as the carbonyl oxygens of Tyr-28, Gly-30, and Gly-32. Aromatic residues are shown in white. Adapted from Dennis ( 9 ). how bts formedWebJan 15, 1996 · The adult frog dorsal root ganglia (DRGs) and their sciatic nerves (ScN) survive in organ culture for several days. About 3 days after a local test crush, the sensory … how bts would hug youWebOct 15, 1994 · Effects of phospholipase A2 inhibitors on the antidepressant-induced axonal regeneration of noradrenergic locus coeruleus neurons In previous experiments, we have … how btus in a tonWebJun 1, 2000 · Cytosolic phospholipase A2 (cPLA2) hydrolyzes the arachidonoyl group from the sn-2 position of glycerophospholipids generating arachidonic acid and … how btu in a tonWebPhospholipase A2 activity is required for regeneration of sensory axons in cultured adult sciatic nerves ... which precedes the outgrowth, was unaffected by BPB. Several structures, including axonal ones, showed immunoreactivity for the low molecular form of PLA 2 (sPLA 2). The results suggest that PLA 2 activity plays an important role in ... how bubble form and psychology effectWebAug 21, 2008 · These results show that, axon regeneration and re-innervation is delayed in the absence of lack of cPLA 2 GIVA and iPLA 2 GVIA. Discussion. The results of this study … how btus do i need for 2400sq ftWebOct 15, 1994 · The effects of the PLA2 inhibitors, mepacrine (MEP) or 4-bromphenacyl bromide (BPB), upon the DMI-induced regeneration of noradrenergic axons in the rat … how many pages is my novel