Chk1 antibody

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August undefined, 2024

WebApr 14, 2024 · Abstract. The concept of “BRCAness” was first described in 2004 to define the situation in which a homologous recombination repair (HRR) defect in a tumor relates to and phenocopies BRCA1 or BRCA2 loss-of-function mutations. Soon after the discovery of synthetic lethality of PARP1/2 inhibitors in BRCA1- or BRCA2-deficient cells, McCabe … WebCHK1 (CHEK1) is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. CHK1 can also phosphorylate p53 at Ser20 in vitro. Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins.

Immune modulating activity of the CHK1 inhibitor prexasertib

WebCHK1 (CHEK1) is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. CHK1 can also phosphorylate p53 at Ser20 in vitro. Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. WebThus, Chk1 and Chk2 activity may be an important checkpoint that inhibits entry into mitosis in response to DNA damage. This antibody is routinely tested by western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature. black nickel challenge coin

Phospho-CHK1 (Ser345) Monoclonal Antibody (S.48.4)

WebMonoclonal Antibody for studying Chk1. Cited in 431 publications. Validated for Western Blotting, Simple Western™. Highly specific and rigorously validated in-house, Chk1 … WebCHEK1 (Checkpoint kinase-1) is also named as CHK1 and belongs to the protein kinase superfamily. It is implicated in a circuit in which it activates checkpoints, DNA repair and proliferating cell nuclear antigen and … WebSee all Chk1 primary antibodies Description Rabbit polyclonal to Chk1 (phospho S317) Host species Rabbit Tested applications Suitable for: IHC-P, WB, ICC/IF more details Species reactivity Reacts with: Human Immunogen Synthetic peptide. This information is proprietary to Abcam and/or its suppliers. Positive control black nickel cup handles

Recombinant Anti-Chk1 antibody [EP691Y] (ab40866) Abcam

CHK1 - 0.1 ML

WebProduct name Anti-Chk1 (phospho S296) antibody [EPR915] See all Chk1 primary antibodies Description Rabbit monoclonal [EPR915] to Chk1 (phospho S296) Host species Rabbit Tested applications Suitable for: WB more details Unsuitable for: ICC/IF or IHC-P Species reactivity Reacts with: Human Immunogen Synthetic peptide. WebChk1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by Chk1 becomes bound by an adaptor protein in … garden city utah newsWebCHK1 (CHEK1) is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. CHK1 can also phosphorylate p53 at Ser20 in vitro. Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. garden city utah stores

"WebCHK1 (CHEK1) is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. CHK1 can also phosphorylate p53 at Ser20 in vitro. Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. " - Chk1 antibody

Chk1 antibody

WebHuman Phospho-Chk1 (S345) Antibody Summary. Detects human, mouse, and rat Chk1 when phosphorylated at S345. This antibody does not recognize Chk1 when … Web1. We have tested different CHK1 antibodies purchased from Santa Cruz Inc. (sc-7898 and sc-8408).Although sc-8408 is good for Western blot, it is not good for immunoprecipitation.We suggest using the polyclonal CHK1 antibody (sc-7898) for CHK1 kinase assay.2. CHK1 protein is expressed specifically during the S and G2 phase of the …

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WebRabbit polyclonal Chk1 antibody. Validated in WB, IHC and tested in Human. Cited in 24 publication(s). Independently reviewed in 3 … WebCHK1. Location: 11q24.2. Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in …

WebCheckpoint kinase 1, or Chk1, is a protein serine/threonine kinase that is an essential component of the ATR pathway, which links DNA abnormalities and double strand breaks to downstream signaling events. It is activated through phosphorylation by ATR at serine residues 345 and 317. Once activated, Chk1 phosphorylates downstream effectors of S ... WebMonoclonal Anti-Chk1 antibody produced in mouse is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections), immunoprecipitation, microarray and western blot at a working concentration of 1-2 μg/mL using whole extract of cultured 293T (human embryonal kidney) cells.

WebIn vitro Chk1 binds to and phosphorylate the dual-specificity protein phosphatases Cdc25A, Cdc25B, and Cdc25C, which control cell cycle transitions by dephosphorylating cyclin-dependent kinases. CHK1 can … WebSep 7, 2024 · Chk1 Antibody (G-4) is a mouse monoclonal IgG 2a κ Chk1 antibody, cited in 800 publications, provided at 200 µg/ml. raised against amino acids 1-476 representing full length Chk1 of human origin. …

WebDetects human, mouse, and rat Chk1 when phosphorylated at S317 in Western blots. Does not recognize Chk1 when unphosphorylated at S317. Source Polyclonal Rabbit IgG Purification Antigen Affinity-purified Immunogen Phosphopeptide containing human Chk1 S317 site Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.

garden city utilities idWebMouse anti Chk1 antibody, clone 2G1D5 recognizes Chk1 also known as cell cycle checkpoint kinase homologue 1, CHK1 or checkpoint kinase-1. Chk1, like the other checkpoint kinase Chk2, is a serine/threonine protein kinase that plays a crucial role in cell cycle control. Chk1 becomes phosphorylated and consequently activated in response to … garden city utah vacation rentalsWebMar 31, 2024 · CHK1 is a key effector kinase in the DDR and is activated through phosphorylation at Ser317 and Ser345 by the ATR kinase upon UV exposure or replication stress [ 4 ]. CHK1 phosphorylates many downstream substrates and is required for maintenance of cell cycle checkpoint as well as cell survival [ 5, 6 ]. garden city utilitiesWebChk1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when … black nickel powder coatWebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free … black nickel plating on brasWebA biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields garden city used car dealersWebAntibody: Affinity purified rabbit anti-CHK1 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB. Biological Strategies: Western Blot: Chk1 Antibody [NB100-464] - Detection of Human Chk1 by Western Blot. … black nickel vs powder coat